New human parvovirus and clinical manifestations, which it causes

I. Dzyublyk, O. Obertynska


Progress in molecular genetic research techniques contributed to the discovery of a new parvovirus, called human bocavirus. First discovered bocavirus HBoV1 was detected and identified by polymerase chain reaction in 2005. Another three bocaviruses HBoV2-4 were identified at first in 2009-2010. The paper presents the newest information about structure, place in the classification and reproduction of bocaviruses. There are described the ways of transmission and features of epidemiology of bocavirus infection. The main clinical manifestations of bocavirus infection in children and adults, as well as laboratory diagnostics, are presented.


new parvovirus; human bocavirus; bocavirus infection; laboratory diagnosis; epidemiology


Allander T, Tammi MT, Eriksson M, et al. Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proc Natl Acad Sei U S A 2005; 102(36): 12891-6.

Kapoor A, Slikas E, Simmonds P, et al. A newly identified bocavirus species in human stool. J Infect Dis 2009; 199(2): 196-200.

Arthur JL, Higgins GD, Davidson GP, et al. A novel bocavirus associated with acute gastroenteritis in Australian children. PLoS Pathog 2009;5(4):e1000391.

Bastien N, Brandt K, Dust K, et al. Human bocavirus infection, Canada. Emerg Infect Dis 2006; 12(5):848-50.

Allander T, Jartti T, Gupta S, et al. Human bocavirus and acute wheezing in children. Clin Infect Dis 2007;44(7):904-10.

Brieu N, Gay B, Segondy M, et al. Electron microscopy observation of human bocavirus (HBoV) in nasopharyngeal samples from HBoV-infected children. J Clin Microbiol 2007;45(10):3419-20.

Lindner J, Modrow S. Human bocavirus—a novel parvovirus to infect humans. Intervirology 2008;51(2):116-22.

Chow BD, Huang YT, Esper FP. Evidence of human bocavirus circulating in children and adults, Cleveland, Ohio. J Clin Virol 2008;43(3):302-6.

Schenk T, Strahm B, Kontny U, et al. Disseminated bocavirus infection after stem cell transplant. Emerg Infect Dis 2007; 13(9): 1425-7.

Monteny M, Niesters HG, Moll HA, et al. Human bocavirus in febrile children, The Netherlands. Emerg Infect Dis 2007; 13(1): 180-2.

Jacques J, Moret H, Renois F, et al. Human bocavirus quantitative DNA detection in French children hospitalized for acute bronchiolitis. J Clin Virol 2008;43(2): 142-7.

Copyright (c) 2018 Health of Society

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2019