Ambroxol in comprehensive treatment of patients with acute respiratory diseases
Keywords:ambroxol hydrochloride, acute respiratory diseases, productive cough, treatment, adults
The article presents data on optimization of pathogenetic therapy in patients with acute respiratory diseases with manifestations of tracheitis, bronchitis and complicated by community-acquired pneumonia in adults. The etiological structure of acute respiratory diseases and resistance to antibacterial preparations are described. The role of ambroxol hydrochloride in comprehensive treatment of patients with acute respiratory diseases with various complications from the respiratory system is shown. It has been established that the use of ambroxol hydrochloride positively affects the basic etiological process, reduces the time of hospital stay due to the rapid termination of bacterial excretion by the average of 3.8 ± 0.7 days in 75 % of patients (p = 0.001).
Unified clinical protocol for primary care for adults and children. Acute respiratory infections. Order of the Ministry of Health of Ukraine. July 16, 2014, № 499.
Kramarev S.O. Approaches to antibacterial therapy of acute respiratory infections in children / Kramarev S.O., Yevtushenko V.V. // Actual infectology. — 2015. — № 1(6). — P. 7-12.
Feshchenko Yu.I. Pneumonia today: clinical variants, etiology and etiotropic therapy / Yu.I. Feshchenko // Treatment and diagnostics. — 2000. — № 2. — P. 18-24.
Simonova O.I., Gorinova Yu.V. Inhalation therapy with ambroxol solution (Lazolvan®): benefits, application specifics, effectiveness // RMJ. — 2014. — № 21. — Р. 1530.
Simonova O.I. Clinical effects of ambroxol hydrochloride (lasolvan®): what does the effectiveness of the drug depend on? // Pediatrics. — 2011. — № 5. — P. 128-133.
Beeh K.M., Beier J., Esperester A., Paul L.D. Antiinflammatory properties of ambroxol // Eur. J. Med. Res. — 2008. — Vol. 13(12). — P. 557-562.
Cataldi M., Sblendorio V., Leo A., Piazza O. Biofilm-dependent airway infections: A role for ambroxol? // Pulm. Pharmacol. Ther. — 2014. — Vol. 28 (2). — P. 98-108.
Malerba M., Ragnoli B. Ambroxol in the 21st Century: Pharmaceutical and clinical update // Expert Opin. Drug Metab. Toxicol. — 2008. — Vol. 4(8). — P. 1119-1129.
Huang J., Xu J., Tian L., Zhong L. A thioredoxin reductase and / or thioredoxin system-based mechanism for antioxidant effects of ambroxol // Biochimie. — 2014. — Vol. 97. — P. 92-103.
Zhang Z.Q., Wu Q.Q., Huang X.M., Lu H. Prevention of respiratory distress syndrome in preterm infants by antenatal ambroxol: a meta-analysis of randomized controlled trials // Am. J. Perinatol. — 2013. — Vol. 30(7). — P. 529-536.
Cunnigham F.M. et al. Effect of Ambroxol on mucociliary transport in the guinea pig // Br. J. Pharmacol. — 1983. — Vol. 80 (Suppl). — P. 693.
Eckert H., Lux M., Lachmann B. The role of alveolar macrophages in surfactant turnover. An experimental study on metabolite VIII of bromhexine (ambroxol) // Lung. — 1983. — Vol. 161. — P. 213-218.
Heath M.F., Jacobson W. The action of lung lysosomal phospholipases is dipalmitoyl phosphatidylcholine and its significance for the synthesis of pulmonary surfactant // Pediatr. Res. — 1980. — Vol. 14. — P. 254-258.
Bonnetti P. Ambroxol plus amoxicillin versus amoxicillin alone in various respiratory tract infections. Investig // Medica Internacional. — 1993. — Vol. 20. — P. 99-103.
Copyright (c) 2018 Health of Society
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our edition uses the copyright terms of Creative Commons for open access journals.
Authors, who are published in this journal, agree with the following terms:
- The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
- Directing the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
- The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
- The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
- The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
- The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.
- The rights to the article are deemed transferred by the authors to the edition (the publisher) since the moment of the publication of the article in the printed or electronic version of journal.