DOI: https://doi.org/10.22141/2306-2436.6.4.2017.123505

The correlation between the VDR gene polymorphism and the level of vitamin D in children with bronchial asthma on the background of overweight or obesity

V.I. Velichko, Yu.A. Pichuhina, Ya.I. Bazhora

Abstract


Background. The purpose was to study the incidence of vitamin D receptor (VDR) gene polymorphism in children with bronchial asthma and to establish correlation links with the level of vitamin D, calcium and clinical manifestations of the di­sease in children. Materials and methods. The study involved 42 children with moderate to severe asthma. The average age of patients was 7.6 ± 1.3 years. The control group included 20 healthy children without any somatic pathology against the background of harmonious physical development, the average age of them was 7.34 ± 0.36 years. Results. The study of VDR gene polymorphism in children with bronchial asthma showed the presence of mutations or heterozygous type of inheritance in the majority of patients with this pathology, a mutation was detected in 64.3 % of patients, 28.5 % of patients showed a heterozygous type of inheritance, 7.2 % had a normal gene distribution. In the control group, mutations were not detected, only 10 % of healthy children had a heterozygous type of inheritance, 90 % of those had a normal gene distribution. A statistically significant relationship was also established between the presence of VDR gene polymorphism and the level of vitamin D. Children with VDR mutation and children who had heterozygous inheritance type had a significantly lower serum vitamin D3 levels (12.10 ± 0.67 ng/ml and 13.53 ± 0.26 ng/ml, respectively) than children with normal gene distribution (32.17 ± 1.05 ng/ml), p < 0.01 for both populations. Pearson’s criterion shows that the relationship between the factor and the outcome is statistically significant, p < 0.01, χ2 criterion = 9.21. Conclusions. The study of the VDR gene polymorphism in children with bronchial asthma showed the presence of mutations or heterozygous type of inheritance in the majority of patients with this pathology. A statistically significant relationship was established between the presence of VDR gene polymorphism and the level of vitamin D, as well as between the presence of polymorphism of the VDR gene and the clinical manifestations of the disease in children.

Keywords


vitamin D; vitamin D receptor; obesity; children; asthma

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