Clinical and epidemiological features of a subclinical hypothyroidism in young people


  • H. M. Kukharchuk Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine,



subclinical hypothyroidism, cardiovascular pathology, dyslipidemia, cardiovascular risk factors, general practitioner - family doctor


Background. The article presents the analysis of the literature data and the results of our own retrospective studies on the spread and clinical features of a subclinical hypothyroidism. The purpose of the study was to evaluate and analyze the clinical and epidemiological features of a subclinical hypothyroidism in young people living in the Kyiv region. Materials and methods. To solve this goal the selection of patients with an autoimmune thyroiditis, which had the same basic characteristics, was carried out. According to the results of a comprehensive examination of 114 patients, 2 groups were created, depending on a thyroid dysfunction and changes in thyroid-stimulating hormone and free tetraiodothyron characteristic of an autoimmune thyroiditis. The first group - 94 patients with subclinical hypothyroidism, the second group - 20 patients in the stage of euthyroidism, the third group - the comparison group, 20 practically healthy persons. The average thyrotropic hormone level in group I was 7,62±0,91 µIU/MI, in group II it was 2,32±1,22 µIU/MI, and in group III it was 1,83±1,11 µIU/MI, respectively. The research methodology was based on a systematic approach and analysis using the methods of semantic evaluation of scientific documents and comparison. Results. As a result of the research it was found that among the surveyed residents of the Kyiv region who have a subclinical hypothyroidism, the largest number live in the Vasylkiv district - 19 (20,21 %), in the Brovary district - 16 (15,95 %) and 12 (12,76 %) - in the Baryshevsky district. Analyzing the clinical and epidemiological features of a subclinical hypothyroidism in young people, the most frequent complaints were: a general weakness (52,12 %), a rapid fatigue (50,0 %), a weight gain (32,98%) and a hair loss (30,85 %) among the patients of group I. Among other complaints, which accounted for 45,74 %, were menstrual disorders, possible changes in blood pressure and lumps in the throat. In the II group of patients surveyed at the primary health care level, the above mentioned complaints were in 10 (20,0 %) patients and in 3 (15,0 %) patients - in group III. Conclusions. According to the latest data, practically the entire territory of Ukraine is in the area of iodine deficiency, which is manifested by various forms of a thyroid dysfunction. General practitioners - family physicians should be alert to the presence of minimal thyroid changes in young patients.


Шекера О. Г. Рання оцінка розвитку кардіоваскулярної патології у безсимптомних пацієнтів із субклінічним гіпотиреозом / О.Г. Шекера, Х.М. Кухарчук // Сімейна медицина. – 2018. - №2 (76). – С. 41-44.

Заремба Є.Х. Cубклінічний гіпотиреоз: лабораторний феномен чи окрема нозологія? / Є.Х. Заремба, І.С. Шатинська-Мицик // Сучасні препарати та технології. – 2010. - №4 (70). - С. 52-55.

Олійник Т.В. Оптимізація діагностики та лікування ішемічної хвороби серця, коморбідної з гіпотиреозом, на підставі визначення клініко-патогенетичної ролі нейрогуморальних та імунозапальних порушень: дис…. кандидата мед. наук: 14.01.02 / Олійник Тетяна Вікторівна. – Запоріжжя: Запорізький державний медичний університет, 2017. – 162 с.

Hak A.E., Pols H.A., Visser T.J. Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam study // Ann. Intern. Med. — 2000. — Vol. 132. — P. 270-278.

Шестакова Т.П. Субклинический гипотиреоз – современный взгляд на проблему / Т.П. Шестакова // РМЖ. - 2016. - №1. - С. 6–8.

Пліговка В.М. Оптимізація діагностики та терапевтичної корекції хворих на гіпертоничну хворобу, ожиріння з аутоімунним тиреоїдитом: дис…. кадидата мед. наук: 14.01.02 / Пліговка Вікторія Миколаївна. – Харків: ДУ «Нацiональний iнститут терапії iменi Л. Т. Малої НАМНУ», 2016. – 141 с.

Сайт «Медицинская статистика» [Електронний ресурс]. – Режим доступу: