The level of circulating immune complexes and phagocytic activity of monocytes in patients with a seasonal allergic rhinitis, which occurs together with a chronic stoneless cholecystitis

Authors

  • T. N. Bondarenko Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine,
  • O. V. Nazar Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine,

DOI:

https://doi.org/10.22141/2306-2436.8.3.2019.192175

Keywords:

seasonal allergic rhinitis, chronic stoneless cholecystitis, circulating immune complexes, transfer factor immunomodulator

Abstract

Background. In patients with a seasonal allergic rhinitis (SAR), quantitative and functional immunological disorders are observed, an increase in the number of indicators that characterize the chronic phase of the inflammatory response. A SAR in 50 % of cases occurs together with a chronic stoneless cholecystitis (CSC), which is a comorbid state, which significantly complicates the pathological process. To date, convincing evidence has been obtained of violations of immunological deficiency in a CSC, which are manifested mainly by a phagocytic dysfunction and an increase in circulating immune complexes (CIC). The purpose was to study the level of circulating immune complexes and a phagocytic activity of monocytes in patients with a seasonal allergic rhinitis, which occurs together with a chronic stoneless cholecystitis. Materials and methods. We observed 68 patients with a SAR on the background of a CSC, in whom the number of low molecular weight, medium molecular weight and high molecular weight circulating immune complexes was determined, including 38 men and 30 women, aged 20 to 60 years - the main group (group 1) and 68 patients, among them 35 men and 33 women, aged 20 to 60 years - the control group that was immunomodulated with the drug "Immodin" - a transfer factor with immunomodulating effect (hereinafter - TFI) on the background of a basic therapy. An indication for the use of a TFI is an immunodeficiency state with impaired cellular immunity in adults and children from the age of 6 months. An one dose of TFI contains the amount of an active substance, which is contained in 200 million donor’s white blood cells. The dose is set based on the results of a previous state of a patient immunity. Results. After the completion of a treatment in the main group of patients with a SAR in the clinical plan, the use of the TFI improved both subjective and objective symptoms among the examined patients, which was generally characterized by the elimination or reduction of the severity of asthenic or astheno-neurotic symptoms, as well as signs of an exacerbation of the chronic inflammatory process in the liver. Based on our data, we can consider pathogenetically substantiated and clinically promi­sing the inclusion of a modern immunoactive drug TFI in the treatment complex for patients with ATS a SAR together with a CSC. Conclusions. The inclusion of the modern immunoactive drug TFI in the treatment complex contributes to the positive dynamics of phagocytosis and CIC.

References

Біловол О. М. Клінічна імунологія та алергологія: навчальний посібник медичних ВНЗ ІV рівня акредитації та медичних факультетів університетів. (За редакцією: член-кореспондента НАМНУ, д.м.н., професора О.М. Біловола, д.м.н., професора П. Г. Кравчуна, д.м.н., професора В.Д. Бабаджана. д.м.н., професора Л.В. Кузнецової) / О.М. Біловол, П. Г. Кравчун, В. Д. Бабаджан, Л. В. Кузнецова [та ін.]. - Харків «Гриф», 2011. – 49 с.

Вороненко Ю. В. Алергологія / Ю. В. Вороненко, Б.М. Пухлик, А. М. Пілецький [та ін.]. (Підручник під редакцією д.м.н., проф. Л. В. Кузнецової. Рекомендовано Міністерством освіти та науки України). – Київ, 2008. – 365 с.

Клінічна та лабораторна імунологія. (Національний підручник: за загальною редакцією д.м.н. Л. В. Кузнецової, д.м.н. В. Д. Бабаджана, д.м.н. В. М. Фролова. – Рекомендовано Міністерством освіти та науки України). – Київ, 2012. – 914 с.

Кузнецова Л. В. Імунологія: національний підручник (за загальною редакцією д.м.н., професора Л.В. Кузнецової, д.м.н., професора В.Д. Бабаджана, член-кореспондента НАМН України, професора Н.В. Харченко) / Л. В. Кузнецова, В. Д. Бабаджан, Н. В. Харченко [та ін.]. – ТОВ «Меркьюрі-Поділля», 2013. – 564 с.

Published

2019-10-01

Issue

Section

Medicine