Pathophysiological association of a functional constipation and metabolic disorders. Perspectives on the pharmacocorrection of digestive system disorders by plant fibers as an example of the use of european plum (prunus domestica)

Authors

  • I. V. Senyuk National University of Pharmacy, Kharkіv, Ukraine,
  • Bashar Jabbar Ali Al-Sahlanee National University of Pharmacy, Kharkіv, Ukraine,
  • O. V. Shovkova National University of Pharmacy, Kharkіv, Ukraine,

DOI:

https://doi.org/10.22141/2306-2436.8.4.2019.192178

Keywords:

review, functional constipation, intestines, liver, pancreas, skin, plant fibers, European plum fruit

Abstract

Background. The search for prokinetics has attracted the attention of medical researchers for several centuries, as impaired motility underlies in the pathogenesis of many diseases, such as gastroesophageal reflux disease, hepatitis, gastric ulcer, irritable bowel syndrome, cancer, etc. The purpose of the study was to study in depth the correlation mechanisms of constipation and other pathologies of the digestive system, as well as ways to implement the pharmacocorrection of these disorders in the conditions of use of vegetable fibers on the example of European plum fruit. Materials and methods. The authors used the following research methods: information-analytical, bibliosemantic, systems approach, structural-logical analysis and comparative content analysis. Results. The analysis of patients for functional constipation is presented, the urgency of the problem of violations of the motor-evacuation function of the intestine and the need to search for new phytoobjects for pharmacocorrection of this pathology are formulated. According to the analysis of literary sources, an important direction of scientific developments was described, aimed at studying the pathophysiological association of chronic constipation and metabolic disorders. In our work were given etiological factors of the occurrence of functional constipation against the background of damage to the hepatic parenchyma and pancreatic tissue. Some possible mechanisms for correlation of gastrointestinal, liver, pancreas and skin disorders are presented. The analysis of the pharmaceutical market of Ukraine on the availability of medicines based on plum showed a limited selection of combined preparations and the absence of monocomponent drugs with a laxative effect, which contain the studied plant raw materials. In the work were given facts from the literature on experimental studies of European plum in patients with chronic constipation, as well as the results of studies on models of liver damage. Also, were presented literature data on the phytochemical characteristics of European plum fruits and the relationship of some biologically active compounds with pharmacological properties. Based on the analysis of literary sources, it was found that European plum is widely distributed and adapted to growing conditions in Ukraine, which indicates a sufficient raw material base and the possibility of using fruits in medical and pharmaceutical practice. Conclusions. According to epidemiological studies and literature analysis, a fairly clear correlation has been found between chronic functional obstruction and a number of metabolic pathologies, the most common of which are liver lesions and pancreas. Some possible mechanisms of correlation of gastrointestinal and liver disorders are presented. Here are some facts from the literature on experimental studies of European plum in patients with chronic constipation and liver damage. Literary data on the prospect of using this raw material in the development of new laxatives with hepatoprotective properties are presented.

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Published

2019-11-01

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Medicine