Pathophysiological association of a functional constipation and metabolic disorders. Perspectives on the pharmacocorrection of digestive system disorders by plant fibers as an example of the use of european plum (prunus domestica)


  • I. V. Senyuk National University of Pharmacy, Kharkіv, Ukraine,
  • Bashar Jabbar Ali Al-Sahlanee National University of Pharmacy, Kharkіv, Ukraine,
  • O. V. Shovkova National University of Pharmacy, Kharkіv, Ukraine,



review, functional constipation, intestines, liver, pancreas, skin, plant fibers, European plum fruit


Background. The search for prokinetics has attracted the attention of medical researchers for several centuries, as impaired motility underlies in the pathogenesis of many diseases, such as gastroesophageal reflux disease, hepatitis, gastric ulcer, irritable bowel syndrome, cancer, etc. The purpose of the study was to study in depth the correlation mechanisms of constipation and other pathologies of the digestive system, as well as ways to implement the pharmacocorrection of these disorders in the conditions of use of vegetable fibers on the example of European plum fruit. Materials and methods. The authors used the following research methods: information-analytical, bibliosemantic, systems approach, structural-logical analysis and comparative content analysis. Results. The analysis of patients for functional constipation is presented, the urgency of the problem of violations of the motor-evacuation function of the intestine and the need to search for new phytoobjects for pharmacocorrection of this pathology are formulated. According to the analysis of literary sources, an important direction of scientific developments was described, aimed at studying the pathophysiological association of chronic constipation and metabolic disorders. In our work were given etiological factors of the occurrence of functional constipation against the background of damage to the hepatic parenchyma and pancreatic tissue. Some possible mechanisms for correlation of gastrointestinal, liver, pancreas and skin disorders are presented. The analysis of the pharmaceutical market of Ukraine on the availability of medicines based on plum showed a limited selection of combined preparations and the absence of monocomponent drugs with a laxative effect, which contain the studied plant raw materials. In the work were given facts from the literature on experimental studies of European plum in patients with chronic constipation, as well as the results of studies on models of liver damage. Also, were presented literature data on the phytochemical characteristics of European plum fruits and the relationship of some biologically active compounds with pharmacological properties. Based on the analysis of literary sources, it was found that European plum is widely distributed and adapted to growing conditions in Ukraine, which indicates a sufficient raw material base and the possibility of using fruits in medical and pharmaceutical practice. Conclusions. According to epidemiological studies and literature analysis, a fairly clear correlation has been found between chronic functional obstruction and a number of metabolic pathologies, the most common of which are liver lesions and pancreas. Some possible mechanisms of correlation of gastrointestinal and liver disorders are presented. Here are some facts from the literature on experimental studies of European plum in patients with chronic constipation and liver damage. Literary data on the prospect of using this raw material in the development of new laxatives with hepatoprotective properties are presented.


Drinnan M., Powell J., Nikkar-Esfahani A., Hea­ding R.C., Doyle J.Gastroesophageal and extraesophageal reflux symptoms: Similarities and differences. Laryngoscope. 2015; 125:424-430. doi: 10.1002/lary.24950.

Drossman D. A., Hasler W. L. Rome IV -Functional GI Disorders: Disorders of Gut-Brain Interaction. Gastroenterology2016;150(6):1257-1261.doi: 10.1053/j.gastro.2016.03.035.

Benninga M. A., Nurko S., Faure C, Hyman E. P., Roberts Ian St. J., Schechter N. L. Childhood Functional Gastrointestinal Disorders: Neonate/Toddler. Gastroenterology. 2016; 150(6):1443-1455. doi:10.1053/j.gastro.2016.02.016.

Hai Wei Xin, Xiu Cai Fang, Li Ming Zhu et al. Diagnosis of functional constipation: Agreement between Rome III and Rome II criteria and evaluation for the practicality. J Dig Dis 2014; 15(6):314-320. doi: 10.1111/1751-2980.12145.

Quigley E. M., Fried M., Gwee K.A. et al. World Gastroenterology Organisation Global Guidelines Irritable Bowel Syndrome: A Global Perspective Update September 2015. J Clin Gastroenterol. 2016; 50:704-713. doi: 10.1097/MCG.0000000000000653.

Заклади Охорони здоров’я та Державна служба статистики України. Захворюваність населення України у 2017 році Статистичний збірник. Сайт URL: › druk › publicat › kat_u › zb_zoz_17 (дата звернення 22.10.19 р.).

Werth B. L., Williams K. A., Pont L. G.A longitudinal study of constipation and laxative use in a community-dwelling elderly population. Arch Gerontol Geriatr. 2015; 60(3):418-24. doi: 10.1016/j.archger.2015.02.004.

Li F., Fu T., Tong W., Zhang A., Li C., Gao Y.Effect of Different Surgical Options on Curative Effect, Nutrition, and Health Status of Patients with SlowTransit Constipation. Int J Colorectal Dis. 2014; 29(12):1551-1556. doi: 10.1007/s00384-014-2014-8.

Sharkey K. A.,Mawe G. M. Neurohormonal signalling in the gastrointestinal tract: new. J Physiol. 2014; 592(14):2923-2925. doi: 10.1113/jphysiol.2014.275487

Łokieć K., Klupińska G., Walecka-Kapica E. Estimation of small intestinal bacterial overgrowth in patients with constipation and diarrhea irritable bowel syndrome. Pol. Merkur. Lekarski. 2014; 36(215):307-310.

Фоминых Ю. А., Шабров А. В.,Успенский Ю. П., Иванов С. В. Функциональный запор у пациентов с метаболическим синдромом. Экспериментальная и клиническая гастроентерологія. 2017. № 143(7), С. 151-154.

Кучерявый Ю. А., Маевская Е. А. Эпидемиологическая и патофизиологическая ассоциация неалкогольного стеатогепатита и функционального запора. Возможно ли избежать полипрагмазии в практике гастроэнтеролога? Гастроэнтерология Санкт-Петербурга. 2016. № 1-2, С. 6-10.

Gentric G., Maillet V., Paradis V.etal. Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease. The Journal of clinical investigation. 2015; 125(3):981-992. doi: 10.1172/JCI73957.

Gentric G., Maillet V., ParadisV. etal. Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease. The Journal of clinical investigation. 2015; 125(3):981-992.doi: 10.1172/JCI73957.

Spahis S., Delvin E., Borys J. M., Levy E.etal. Oxidative stress as a critical factor in nonalcoholic fatty liver disease pathogenesis. Antioxidants & Redox Signaling. 2017; 26(10):519-541. doi: 10.1089/ars.2016.6776.

Vajro P., Paolella G., Fasano A. Microbiota and gut-liver axis: their influences on obesity and obesity-related liver disease. J. Pediatr. Gastroenterol. Nutr. 2013;56:461-468. doi: 10.1097/MPG.0b013e318284abb5.

Селиверстов П. В., Ситкин С. И., Радченко В. Г. Роль дисбиоза кишечника в развитии митохондриальной дисфункции и неалкогольной жировой болезни печени // Медицинский Совет. 2018. № 6, С. 89-95. doi:10.21518/2079-701X-2018-6-85-95.

Tack J., Corsetti M. Prucalopride: evaluation of the pharmacokinetics, pharmacodynamics, efficacy and safety in the treatment of chronic constipation. Exp. Opin. Drug Metab. Toxicol 2012;8(10):1327-1335. doi: 10.1517/17425255.2012.719497.

Del Campo J. A., Gallego P., Grande L. Roleofinflammatoryresponseinliverdiseases: Therapeuticstrategies. Worldjournalofhepatology. 2018; 10(1):1-7. doi: 10.4254/wjh.v10.i1.1

Ивашкин В. Т., Гастроэнтерология. Национальное руководство: краткое издание. Москва: ГЭОТАР-Медиа. 2015. С. 480.

Барановский А. Ю. Диетология. 4-е изд.Санкт-петербург: Питер, 2012. С. 1024.

Масловский Л.В. Хронический панкреатит. Новые данные.Медицинский Совет. 2016. № 14, С. 32-35. doi:10.21518/2079-701X-2016-14-32-35

Біохімія: підручник / за заг.ред. проф. А. Л. Загайка, проф. К. В. Александрової. Харків: Форт, 2014. 728 с.

Дерматологія, венерологія: підручник / за ред. проф. В. І. Степаненка. Київ: КІМ, 2012.С. 344-374.

Караулов А. В., Быков С. А., Быков А. С. Иммунология, микробиология и иммунопатологиякожи. Москва: Бином, 2012. 328 с.

Коновалова Т. С. Стан мікробіоценозу кишечника у хворих на вугрову хворобу та вплив його порушень на клінічний перебіг дерматозу. Український журнал дерматології, венерології, косметології. 2014. № 1(52), С. 41-47.

Бабак О. Я., Фадеенко Г. Д., Сытник К. А. Роль пробиотических продуктов питания в профилактике и лечении функциональных запоров. Сучасна гастроентерологія. 2012. № 5(67),C. 116-119.

Attaluri A., Donahoe R., Valestin J., Brown K., Rao S. Randomised clinical trial: dried plums (prunes) vs. psyllium for constipation. Alimentary pharmacology & therapeutics. 2011; 33(7):822-828. doi: 10.1111/j.1365-2036.2011.04594.

Лукієнко О. В., Соколова А. Є., Горбань О. М. Аналіз вітчизняного фармацевтичного ринку препаратів на основі сливи. Фітотерапія. 2012. №. 1, С. 86-89.

Тураева Н. И. Лечебные свойства сливы. Биология и интегративная медицина». 2017. № 1, С 314-320.

Нормативно-директивні документи МОЗ України.Сайт URL: (дата звернення 15.11.19 р.).

Shahm B. M., Upyr T. V., Shapoval O. M., Lenchyk L. V., Georgiev K. Determination of phenolic compounds in Prunus domestica fruits extract and its pharmacological activity. J of IMAB. 2019; 25(2):2589-2594. doi:

Спосіб одержання водорозчинного полісахаридного комплексу з послаблюючою активністю з плодів сливи домашньої: пат. на винахід №118602 Україна. А. М. Комісаренко, Т. В. Упир, І. В. Сенюк, Башар Джабар Алі-Сахлані, Мохаммед Шахм Басім, Л. В. Ленчик. Заявл. 06.03.2017; опубл. 11.02.2019, Бюл. №3.

Celik F., Gundogdu M., Alp S. et. al. Determination of phenolic compounds, antioxidant capacity and organic acids contents of Prunus domestica L., Prunus cerasifera Ehrh. and Prunus spinosa L. fruits by HPLC. Acta Chromatographica. 2017; 29(4):507-510.

doi: 10.1556/1326.2017.00327

Ahmed T., Sadia H., Khalid A., Batool S., Janjua A. Report: prunesand liver function: a clinical trial.Pak. J. Pharm. Sci. 2010;.23:463-466.

Kahlon T. S., Smith G. E. In vitro binding of bile acids by blueberries (Vaccinium spp.), plums (Prunus spp.), prunes (Prunus spp.), strawberries (Fragaria X ananassa), cherries (Malpighia punicifolia), cranberries (Vaccinium macrocarpon) and apples (Malus sylvestris). Food Chem. 2007;.100:1182-1187. doi: 10.1016/j.foodchem.2005.10.066.

El-Beltagi H. S., El-Ansary A. E., Mostafa M. A., Kamel T. A., Safwat G. Evaluation of the Phytochemical, Antioxidant, Antibacterial and Anticancer Activity of Prunus domestica Fruit. Notulae Botanicae Horti Agrobotanici Cluj-Napoca. 2018; 47(2):395-404.

Tanaka T., Tanaka T., Tanaka M. Potential cancer chemopreventive activity of protocatechuic acid. Journal of Experimental & Clinical Medicine. 2011; 3(1):27-33. doi: 10.1016/j.jecm.2010.12.005.

Bose M., Kamra M., Mullick R., Bhattacharya S., Daset S., Anjali A. Karande. Identification of a flavonoid isolated from plum (Prunus domestica) as a potent inhibitor of Hepatitis C virus entry. Scientific Reports. 2017; 7(1):3965. doi: 10.1038/s41598-017-04358-5

Jabeen Q., Aslam N. The pharmacological activities of prunes: The driedplums. Journal of Medicinal Plants Research. 2011; 5(9):1508-1511.