Features of the clinical course, diagnosis and prediction of an osteoarthrosis in various variants of a vitamin D receptor gene polymorphism

Authors

  • K. I. Tereshkin Kharkov National Medical University of the Ministry of Health of Ukraine, Kharkov, Ukraine,
  • L. B. Cherkashina Kharkov Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine, Kharkov, Ukraine Karazin Kharkiv National University of the Ministry of Education and Science of Ukraine, Kharkov, Ukraine,
  • O. S. Komissarova Shupik National Medical Academy of Postgraduate Education, Kyiv, Ukraine,
  • L. A. Smolina Shupik National Medical Academy of Postgraduate Education, Kyiv, Ukraine,

DOI:

https://doi.org/10.22141/2306-2436.8.4.2019.192181

Keywords:

vitamin D receptor gene polymorphism, osteoarthrosis, obesity, apelin

Abstract

According to the results of an in-depth clinical examination of 96 patients, it was found that patients with a homozygous ge­notype BB prevailed, the frequency of which was significantly higher than homozygotes with the bb genotype and the Bb genotype (respectively, 45.8 ± 5.1%, 19.8 ± 4 , 1% and 34.4 ± 4.8%, p <0.05). The absence of violations of the structural and functional state of bone tissue (SFS BT) was recorded in 37.5 ± 4.9% of the examined with osteoarthritis (OA), including 27.2% of BB homozygotes, 68.4% of bb homozygotes and 30.3% of heterozygotes, and Allele B genotype increases the relative risk of a more pronounced lesion of the articular cartilage. A generalized analysis of the severity index of osteoarthritis (W,%) and its components in patients with different variants of the VDR gene polymorphism revealed a significantly higher level of pain manifestations among homozygotes in the second allele, compared with homozygotes in the first allele (52.3 ± 4, respectively 3% and 39.7 ± 2.9%, p <0.05), as well as manifestations of stiffness (57.1 ± 4.6% and 36.2 ± 3.7%, p <0.05, respectively). In homozygotes, the second allele was also diagnosed with significantly more expressive limitations of daily activity (54.2 ± 4.4% and 44.3 ± 4.3%, respectively, p <0.05). Patients with critically excessive body mass (BM) to the greatest degree (more than 45.0%) were represented by homozygotes for the second allele; homozygotes for the second allele also significantly prevailed among individuals with obesity (OB) I st. (respectively, 15.6 ± 3.7% and 16.7 ± 3.8%). The general patterns of serum apelin hormone content in patients with OA depending on the BM index and the variant polymorphism of the VDR gene are characterized by the fact that in the case of bb homozygosity, with increasing body weight, the apelin content increases, while with BB homozygosity with an increase in BMI, it is high the level of apelin does not change. The relationship between the VDR gene polymorphism and the OA stage (as the radiological equivalent of the severity of the process) was characterized by a predominance of more severe radiological manifestations of articular cartilage damage in homozygous BB alleles and heterozygous patients.

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Published

2019-11-01

Issue

Section

Medicine