«Microbiota era» for public health

Authors

  • I.E. Dovganiuk National Pirogov Memorial Medical University, Vinnytsya, Ukraine
  • K.V. Hyrenko National Pirogov Memorial Medical University, Vinnytsya, Ukraine
  • O.J. Dovganjuk National Pirogov Memorial Medical University, Vinnytsya, Ukraine

DOI:

https://doi.org/10.22141/2306-2436.9.4.2020.219249

Keywords:

microbiota, integral model, gastrointestinal tract, prevention, public health

Abstract

Background. The coming decades are recognized to be the "microbiota era", a period of effective work of specialized scientific institutions around the world including Europe, with rapid growth of important aspects of various microbiota being discovered, using new non-cultural molecular genetic methods of diagnostics. The urgency of the research is to attract attention of medical community to scientific and practical potential of human microbiome. The application of integral model for systematization of diseases influenced by microbiota, as well as modulation of factors providing positive potential for human health, will optimize the quality of population health and the level of health of society. The purpose of the study was to assess the potential of human microbiome and substantiate the priority of integral model for studying the impact of microbiota on the human organism and the health of society as a whole. Materials and methods. Application of complex approach study methods, systemic analysis and own observations. Results. On the basis of integral perception of human microbiome, its colonization of organs and systems with a wide range of their mutual influence is clarified. The article focuses on the prospects and features of diagnostic methods, systematization of diseases influenced by microbiota, taking into account their comorbidity. Gut microbiota is characterized in details, it being a frequent predictor of definite diseases of organs and systems. Ways of screening optimization measures to prevent imbalance in biocenosis have been worked out which are supposed to help clinicians in promoting human health preservation. Conclusions. The suggested conceptual model of integral approach will extend understanding of microbiota impact degree on human health, prediction of disease and its course. Effective professional cooperation of scientists (availability of screening methods) and clinicians (wide use of integral system of preventive measures, modulation of microbiota) will improve the potential of human health and, accordingly, the level of public health as a whole.

References

Анохіна Г.А. Синдром підвищеної кишкової проникності: акцент на мікробіоту // Сучасна гастроентерологія. – 2018. – №4(102)

Рудіченко В. М., Тодорашко І.І., Черватюк В.В. Кишечна мікрофлора: вплив на неї пробіотиків та пребіотиків // «Ліки України». – 2014. – №9 (185).

Янковский Д.С. Микробная экология новорожденных: особенности формирования микробиома и профилактика его нарушений / Д.С. Янковский, Ю.Г. Антипкин, Г.С. Дымент, и соавт. // Неонатологія, хірургія та перинатальна медицина. – 2015. – Т. 5. – No 2. – С. 93-105.

Колеснікова О.В., Запровальна О.Є., Лавренко Т.А. «Мікробіота – здоров’я» в літніх людей: чи існує взаємозв’язок // Раціональна фармакотерапія. – 2019. – 1-2 (50-51).

Ткач С.М., Тимошенко О.С., Дорофеєва А.А. Роль кишкової мікробіоти у розвитку ожиріння та інсулінорезистентності Ж:Клінічна ендокринологія та ендокринна хірургія 1 (53) 2016

Янковский Д.С. Микробиом / Д.С. Янковский, В.П. Широбоков, Г.С. Дымент. – К.: ФЛП Верес О.И., 2018. – 640 с.

Barko, P.C., McMichael, M.A., Swanson, K.S., & Williams, D.A. The Gastrointestinal Microbiome: A Review. // J. Vet. Intern. Med. – 2018. – 32 (1), 9-25.

Franzosa, E. A. et al. Gut microbiome structure and metabolic activity in inflammatory bowel disease. // Nat. Microbiol. – 2019. – 4, 293–305.

Jefferson, K. K. et al. Relationship between vitamin D status and the vaginal microbiome during pregnancy. // J. Perinatol. – 2019. – https://doi.org/10.1038/s41372-019-0343-8.

Brown, R. G. et al. Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin. // BMC Med. – 2018. – 16, 9.

Genetic determinants of the gut microbiome in UK twins / J. K. Goodrich, E. R. Davenport, M. Beaumont [et al.] // Cell Host Microbe. – 2016. – N 19. – Р. 731–743.

Choi H. H. Fecal microbiota transplantation: Current applica- tions, effectiveness, and future perspectives / H. H. Choi, Y. S. Cho // Clin. Endosc. – 2016. – N 49. – Р. 257–265.

Vatanen, T. et al. The human gut microbiome in early-onset type 1 diabetes from the TEDDY study. // Nature. – 2018. – 562, 589–594.

Mor, G., Aldo, P. & Alvero, A. B. The unique immunological and microbial aspects of pregnancy. // Nat. Rev. Immunol. – 2018. – 17, 469–482.

Lloyd-Price J, Abu-Ali G, Huttenhower C. The healthy human microbiome. // Genome Med. 2016;8:51. doi: 10.1186/s13073-016-0307-y. - DOI - PMC – PubMed.

Gensollen T, Iyer SS, Kasper D L, Blumberg RS. How colonization by microbiota in early life shapes the immune system. // Science. – 2016;352:539–544. doi: 10.1126/science.aad9378. - DOI - PMC – PubMed

Honda K, Littman DR. The microbiota in adaptive immune homeostasis and disease. Nature. – 2016;535:75–84. doi: 10. 1038/nature18848. - DOI – PubMed

Dickson, R. P. The microbiome and critical illness. // Lancet Respir. Med. – 2016. – 4 (1): 59- 72. doi:10.1016/S2213-2600(15)00427-0

Vo Van. Microbiota and Their Neuroinflammatory Implications in Alzheimer’s Disease / Vo Van, Giau, Si, Ying Wu, Angelo, Jamerlan, Seong,Soo A. An, Sang,Yun Kim, & John, Hulme Gut // Nutrients. – 2018. – 10(11). 1765. https://doi.org/10.3390/nu10111765

Wang, H.-X., Wang, Y.-P. (2016). Gut Microbiota-brain Axis. // Chinese Medical Journal, 129 (19), 2373-2380. http://doi.org/10.4103/0366-6999.190667

Spychala, M. S., Venna, V. R., Jandzinski, M., et al. Age-related changes in the gut microbiota influence systemic inflammation and stroke outcome. // Annals of neurology. – 2018. – 84(1), 23-36. https://doi.org/10.1002/ana.25250

Sochocka, M., Donskow-Łysoniewska, K., Diniz, et al. The gut microbiome alterations and inflammation-driven pathogenesis of Alzheimer’s disease – a critical review. // Molecular neurobiology. – 2019. – 56(3), 1841-1851. https://doi.org/10.1007/s12035-018-1188-4

Martinez-Guryn K. Small intestine microbiota regulate host digestive and absorp- tive adaptive responses to dietary lipids / K. Martinez-Guryn, N. Hubert, K. Frazier [et al.] // Cell Host & Microbe. – 2018. – N 23(4). – P. 458. – DOI: 10.1016/j.chom.2018.03.011.

Turnbaugh PJ, Ley RE, Hamady M, et al. The human microbiome project. // Nature. –2007; – 449(7164):804–810. – doi: 10.1038/ nature06244

Clarke G, Stilling RM, Kennedy PJ, et al. Minireview: Gut microbiota: the neglected endocrine organ. // Mol Endocrinol. – 2014; – 28(8):1221–1238. – doi: 10.1210/me.2014-1108.

Lim MY, Rho M, Song YM, et al. Stability of gut enterotypes in Korean monozygotic twins and their association with biomarkers and diet. // Sci Rep. – 2014; – 4:7348. – doi: 10.1038/srep07348.

Kristensen K, Henriksen L. Cesarean section and disease associated with immune function. // J Allergy Clin Immunol. – 2016; – 137(2): 587–590. – doi: 10.1016/j.jaci.2015.07.040.

Romano-Keeler J, Weitkamp JH. Maternal influences on fetal microbial colonization and immune development. // Pediatr Res. – 2015; – 77(1–2):189–195. – doi: 10.1038/pr.2014.163.

Yang I. The infant microbiome: Implications for infant health and neu- rocognitive development / I. Yang, E. J. Corwin, P. A. Brennan [et al.] // Nurs. Res. – 2016. – N 65. – Р. 76–88.

Published

2020-10-01

Issue

Section

Мedicine